Crystal Mackall

Crystal Mackall is the Ernest and Amelia Gallo Family Professor of Pediatrics and Internal Medicine at Stanford University. She serves as Founding Director of the Stanford Center for Cancer Cell Therapy, Associate Director of Stanford Cancer Institute, Leader of the Cancer Immunology and Immunotherapy Program, and Director of the Parker Institute for Cancer Immunotherapy at Stanford. During a 27-year tenure at NCI, culminating as Chief of the Pediatric Oncology Branch, and now at Stanford, she has led an internationally recognized translational research program focused on immuno-oncology. She has led numerous early phase and first-in-human and first-in-child clinical trials spanning dendritic cell vaccines, cytokines, and adoptive immunotherapy using NK cells and genetically modified T cells. Working with colleagues at NCI, her group was among the first to demonstrate the impressive activity of CD19-CAR in pediatric leukemia (Lee, Lancet 2014). Dr. Mackall’s lab invented the CD22-CAR which is the focus of this license application (Haso, Blood 2014), and Dr. Mackall played a leading role in the NCI clinical trial of the CD22-CAR (Fry, Nat Med 2018; Shah, JCO, 2020). She also contributed to the invention of the CD19/22 bispecific and bicistronic CARs and led the first two clinical trials of the CD19/22 bispecific-CAR at Stanford.

Dr. Mackall is a member of the American Society of Clinical Investigation, and the American Academy of Physicians and received the Lila and Murray Gruber Award for Cancer Research in 2019. She serves in numerous national leadership positions, including co-PI on the NCI Pediatric Cancer Immunotherapy Network (U54), Leader of the NCI Pediatric Cancer Immunotherapy Trials Network, and co-Leader of the St. Baldrick’s-StandUp2Cancer Pediatric Dream Team. She is Board Certified in Pediatrics, Pediatric Hematology-Oncology, and Internal Medicine.

She has served on numerous biotechnology and pharmaceutical company scientific advisory boards and previously co-founded Lyell Immunopharma, which is developing next-generation CAR-T cells.

She attended Northeast Ohio Medical University (NEOMED).

Crystal Mackall is the Leader, Pediatric Cancer Immunotherapy Trials Network at National Cancer Institute, based in United States, North America. With a background in Education, Crystal Mackall has a rich history of leadership and innovation. Explore their detailed professional journey, key connections, and contributions to the industry on our platform.